Vibrio cholerae Serogroup Non-Ol is a bacterium that infects only humans and other primates. It is akin to Vibrio cholerae Serogroup O1, which is the organism that triggers Asiatic or widespread cholera, but initiates an illness documented to be less serious than cholera as examined by means of microscopy using a microscope such as compound monocular microscope. Both pathogenic and nonpathogenic strains of the organism are typical inhabitants of marine and estuarine surroundings of America. This organism has been passed on to as non-cholera vibrio or NCV and nonagglutinable vibrio or NAG in the past, even though not less than 139 O serogroups have been recognized. The Non-Ol Vibrio cholerae gastroenteritis is the terminology linked with this disease. Although rare, septicemic contaminations have been documented and fatalities have ensued. Certain cases are similar to the primary septicemia initiated by Vibrio vulnificus. Diarrhea, fever and abdominal cramps are the major manifestations linked with this illness, with vomiting and nausea happening in about twenty-five percent of infected persons. About twenty-five of infected persons will have blood and mucus in their feces as examined by means of microscopy under a microscope such as compound monocular microscope. Diarrhea may in certain instances be moderately severe, lasting six to seven days. Diarrhea will commonly happen within forty-eight hours following consumption of the organism. It is not known how the organism initiates the disease, although an enterotoxin is alleged as well as an intrusive strategy. Illness is initiated when the organism connects itself to the small intestine of contaminated persons and perhaps subsequently infiltrates. Illness triggered by Vibrio cholerae O139 is impossible to differentiate from cholera triggered by Vibrio cholerae O1 as viewed through microscopy using a microscope such as compound monocular microscope. The infective dose is alleged to be in large numbers presumably over one million of the organism should be swallowed to cause the disease as examined through microscopy under a microscope such as compound monocular microscope. Diagnosis of a Vibrio cholerae non-Ol contamination is done by culturing the organism from a person’s diarrheic feces or from the blood of patients with septicemia and then viewed under the microscope like the compound monocular microscope. Shellfish collected from the coastal waters of America oftentimes have Vibrio cholerae serogroup non-Ol. Ingestion of raw, uncooked, or not properly cooked, re-contaminated shellfish can lead to contamination. No major epidemics of diarrhea have been associated to this organism. Occasional cases happen oftentimes mainly along the coasts of America and are commonly connected with the ingestion of raw oysters during the warmer months. Diarrhea ensuing from swallowing of the organism typically seven days and is self-limiting. Antibiotics like tetracycline shorten the severity and extent of the disease. Septicemia where bacteria gains entry into the blood stream and proliferate therein may happen. This complication is connected with persons suffering from cirrhosis of the liver or who are or who are immunosuppressed but this is comparatively rare. Every person who eats raw shellfish is vulnerable to diarrhea caused by this organism. Cirrhotic or immunosuppressed persons can form serious complications like septicemia. Techniques utilized to isolate this organism from foods are analogous to those utilized with diarrheic feces where samples are being examined by means of microscopy using a microscope such as compound monocular microscope. Since numerous food isolates are nonpathogenic, pathogenicity of every food isolates should be illustrated. All virulence strategies of this group have not been explicated therefore pathogenicity examination should be done in suitable animal models.